Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB

Reduced expression of brain-derived neurotrophic factor (BDNF) and impaired activation of the BDNF receptor, tropomyosin receptor kinase B (TrkB; also known as Ntrk2), are thought to contribute significantly to the pathophysiology of Rett syndrome (RTT), a severe neurodevelopmental disorder caused b...

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Vydáno v:Dis Model Mech
Hlavní autoři: Adams, Ian, Yang, Tao, Longo, Frank M., Katz, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710018/
https://ncbi.nlm.nih.gov/pubmed/33361117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.044685
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