A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in methyl-CpG-binding protein-2 (MECP2), a transcriptional regulator of many genes, including brain-derived neurotrophic factor (BDNF). BDNF levels are reduced in RTT autopsy brains and in multiple brain areas of Mecp2-deficien...

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Bibliographische Detailangaben
Veröffentlicht in:Dis Model Mech
Hauptverfasser: Li, Wei, Bellot-Saez, Alba, Phillips, Mary L., Yang, Tao, Longo, Frank M., Pozzo-Miller, Lucas
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536912/
https://ncbi.nlm.nih.gov/pubmed/28679669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.029959
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