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MPTP-induced changes in hippocampal synaptic plasticity and memory are prevented by memantine through the BDNF-TrkB pathway

BACKGROUND AND PURPOSE: Mild cognitive deficit in early Parkinson's disease (PD) has been widely studied. Here we have examined the effects of memantine in preventing memory deficit in experimental PD models and elucidated some of the underlying mechanisms. EXPERIMENTAL APPROACHES: I.p. injecti...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Br J Pharmacol
मुख्य लेखकों: Zhu, Guoqi, Li, Junyao, He, Ling, Wang, Xuncui, Hong, Xiaoqi
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BlackWell Publishing Ltd 2015
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403099/
https://ncbi.nlm.nih.gov/pubmed/25560396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13061
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