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MPTP-induced changes in hippocampal synaptic plasticity and memory are prevented by memantine through the BDNF-TrkB pathway
BACKGROUND AND PURPOSE: Mild cognitive deficit in early Parkinson's disease (PD) has been widely studied. Here we have examined the effects of memantine in preventing memory deficit in experimental PD models and elucidated some of the underlying mechanisms. EXPERIMENTAL APPROACHES: I.p. injecti...
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| 出版年: | Br J Pharmacol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BlackWell Publishing Ltd
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4403099/ https://ncbi.nlm.nih.gov/pubmed/25560396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13061 |
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