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MPTP-induced changes in hippocampal synaptic plasticity and memory are prevented by memantine through the BDNF-TrkB pathway

BACKGROUND AND PURPOSE: Mild cognitive deficit in early Parkinson's disease (PD) has been widely studied. Here we have examined the effects of memantine in preventing memory deficit in experimental PD models and elucidated some of the underlying mechanisms. EXPERIMENTAL APPROACHES: I.p. injecti...

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書誌詳細
出版年:Br J Pharmacol
主要な著者: Zhu, Guoqi, Li, Junyao, He, Ling, Wang, Xuncui, Hong, Xiaoqi
フォーマット: Artigo
言語:Inglês
出版事項: BlackWell Publishing Ltd 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403099/
https://ncbi.nlm.nih.gov/pubmed/25560396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13061
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