A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in methyl-CpG-binding protein-2 (MECP2), a transcriptional regulator of many genes, including brain-derived neurotrophic factor (BDNF). BDNF levels are reduced in RTT autopsy brains and in multiple brain areas of Mecp2-deficien...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Dis Model Mech
Egile Nagusiak: Li, Wei, Bellot-Saez, Alba, Phillips, Mary L., Yang, Tao, Longo, Frank M., Pozzo-Miller, Lucas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Company of Biologists Ltd 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536912/
https://ncbi.nlm.nih.gov/pubmed/28679669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.029959
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