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RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly

The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase-1 activation and interleukin (IL)-1β maturation in response to microbial infection and cellular damage. However, aberrant activation of the NLRP3 inflammasome contributes to the pathogenesis of several inflamma...

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Bibliografski detalji
Izdano u:Cell Rep
Glavni autori: Duan, Yanhui, Zhang, Lingzhi, Angosto-Bazarra, Diego, Pelegrín, Pablo, Núñez, Gabriel, He, Yuan
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709964/
https://ncbi.nlm.nih.gov/pubmed/33207200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108405
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