The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations

BACKGROUND: Crenolanib (crenolanib besylate, 4-piperidinamine, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-, monobenzenesulfonate) is a potent and specific type I inhibitor of fms-like tyrosine kinase 3 (FLT3) that targets the active kinase conformation and is effectiv...

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Publicado en:Invest New Drugs
Main Authors: Mathias, Trevor J., Natarajan, Karthika, Shukla, Suneet, Doshi, Kshama A., Singh, Zeba N., Ambudkar, Suresh V., Baer, Maria R.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709138/
https://ncbi.nlm.nih.gov/pubmed/25597754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-015-0205-y
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