Tethering-facilitated DNA ‘opening’ and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein

XPC/Rad4 initiates eukaryotic nucleotide excision repair on structurally diverse helix-destabilizing/distorting DNA lesions by selectively ‘opening’ these sites while rapidly diffusing along undamaged DNA. Previous structural studies showed that Rad4, when tethered to DNA, could also open undamaged...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Paul, Debamita, Mu, Hong, Tavakoli, Amirrasoul, Dai, Qing, Chen, Xuejing, Chakraborty, Sagnik, He, Chuan, Ansari, Anjum, Broyde, Suse, Min, Jung-Hyun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Structural Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708039/
https://ncbi.nlm.nih.gov/pubmed/33119737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa909
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi