Tethering-facilitated DNA ‘opening’ and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein

XPC/Rad4 initiates eukaryotic nucleotide excision repair on structurally diverse helix-destabilizing/distorting DNA lesions by selectively ‘opening’ these sites while rapidly diffusing along undamaged DNA. Previous structural studies showed that Rad4, when tethered to DNA, could also open undamaged...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Paul, Debamita, Mu, Hong, Tavakoli, Amirrasoul, Dai, Qing, Chen, Xuejing, Chakraborty, Sagnik, He, Chuan, Ansari, Anjum, Broyde, Suse, Min, Jung-Hyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708039/
https://ncbi.nlm.nih.gov/pubmed/33119737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa909
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