Kinetic gating mechanism of DNA damage recognition by Rad4/XPC

The xeroderma pigmentosum C (XPC) complex initiates nucleotide excision repair by recognizing DNA lesions before recruiting downstream factors. How XPC detects structurally diverse lesions embedded within normal DNA is unknown. Here we present a crystal structure that captures the yeast XPC ortholog...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Chen, Xuejing, Velmurugu, Yogambigai, Zheng, Guanqun, Park, Beomseok, Shim, Yoonjung, Kim, Youngchang, Liu, Lili, Van Houten, Bennett, He, Chuan, Ansari, Anjum, Min, Jung-Hyun
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Pub. Group 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354021/
https://ncbi.nlm.nih.gov/pubmed/25562780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6849
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk