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Kinetic gating mechanism of DNA damage recognition by Rad4/XPC
The xeroderma pigmentosum C (XPC) complex initiates nucleotide excision repair by recognizing DNA lesions before recruiting downstream factors. How XPC detects structurally diverse lesions embedded within normal DNA is unknown. Here we present a crystal structure that captures the yeast XPC ortholog...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Pub. Group
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4354021/ https://ncbi.nlm.nih.gov/pubmed/25562780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6849 |
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