Kinetic gating mechanism of DNA damage recognition by Rad4/XPC

The xeroderma pigmentosum C (XPC) complex initiates nucleotide excision repair by recognizing DNA lesions before recruiting downstream factors. How XPC detects structurally diverse lesions embedded within normal DNA is unknown. Here we present a crystal structure that captures the yeast XPC ortholog...

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Pubblicato in:Nat Commun
Autori principali: Chen, Xuejing, Velmurugu, Yogambigai, Zheng, Guanqun, Park, Beomseok, Shim, Yoonjung, Kim, Youngchang, Liu, Lili, Van Houten, Bennett, He, Chuan, Ansari, Anjum, Min, Jung-Hyun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354021/
https://ncbi.nlm.nih.gov/pubmed/25562780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6849
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