Structural Optimization of Polymeric Carriers to Enhance the Immunostimulatory Activity of Molecularly Defined RIG-I Agonists

[Image: see text] RNA ligands of retinoic acid-inducible gene I (RIG-I) hold significant promise as antiviral agents, vaccine adjuvants, and cancer immunotherapeutics, but their efficacy is hindered by inefficient intracellular delivery to the cytosol where RIG-I is localized. Here, we address this...

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Udgivet i:ACS Cent Sci
Main Authors: Jacobson, Max E., Becker, Kyle W., Palmer, Christian R., Pastora, Lucinda E., Fletcher, R. Brock, Collins, Kathryn A., Fedorova, Olga, Duvall, Craig L., Pyle, Anna M., Wilson, John. T.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7706089/
https://ncbi.nlm.nih.gov/pubmed/33274278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c00568
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