Amphiphilic Polyelectrolyte Graft Copolymers Enhance the Activity of Cyclic Dinucleotide STING Agonists

Cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) hold great therapeutic potential, but their activity is hindered by poor drug-like properties that restrict cytosolic bioavailability. Here, we address this challenge through the synthesis and evaluation of a novel series o...

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Pubblicato in:Adv Healthc Mater
Autori principali: Nguyen, D. Chuong, Shae, Daniel, Pagendarm, Hayden M., Becker, Kyle W., Wehbe, Mohamed, Kilchrist, Kameron V., Pastora, Lucinda E., Palmer, Christian R., Seber, Pedro, Christov, Plamen P., Duvall, Craig L., Wilson, John T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856189/
https://ncbi.nlm.nih.gov/pubmed/33225632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.202001056
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