Endosomolytic Polymersomes Increase the Activity of Cyclic Dinucleotide STING Agonists to Enhance Cancer Immunotherapy

Cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) are a promising class of immunotherapeutic that activate innate immunity to increase tumor immunogenicity. However, the efficacy of CDNs is limited by drug delivery barriers, including poor cellular targeting, rapid clearan...

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Publicat a:Nat Nanotechnol
Autors principals: Shae, Daniel, Becker, Kyle W., Christov, Plamen, Yun, Dong Soo, Lytton-Jean, Abigail K.R., Sevimli, Sema, Ascano, Manuel, Kelley, Mark, Johnson, Douglas B., Balko, Justin M., Wilson, John T.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402974/
https://ncbi.nlm.nih.gov/pubmed/30664751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41565-018-0342-5
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