Endosomolytic Polymersomes Increase the Activity of Cyclic Dinucleotide STING Agonists to Enhance Cancer Immunotherapy

Cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) are a promising class of immunotherapeutic that activate innate immunity to increase tumor immunogenicity. However, the efficacy of CDNs is limited by drug delivery barriers, including poor cellular targeting, rapid clearan...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Nanotechnol
Egile Nagusiak: Shae, Daniel, Becker, Kyle W., Christov, Plamen, Yun, Dong Soo, Lytton-Jean, Abigail K.R., Sevimli, Sema, Ascano, Manuel, Kelley, Mark, Johnson, Douglas B., Balko, Justin M., Wilson, John T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402974/
https://ncbi.nlm.nih.gov/pubmed/30664751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41565-018-0342-5
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