Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus

The mechanistic target of rapamycin complex 1 (mTORC1) integrates growth, nutrient and energy status cues to control cell growth and metabolism. While mTORC1 activation at the lysosome is well characterized, it is not clear how this complex is regulated at other subcellular locations. Here, we combi...

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Publicat a:Nat Commun
Autors principals: Zhou, Xin, Zhong, Yanghao, Molinar-Inglis, Olivia, Kunkel, Maya T., Chen, Mingyuan, Sun, Tengqian, Zhang, Jiao, Shyy, John Y.-J., Trejo, JoAnn, Newton, Alexandra C., Zhang, Jin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705703/
https://ncbi.nlm.nih.gov/pubmed/33257668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19937-w
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