Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus

The mechanistic target of rapamycin complex 1 (mTORC1) integrates growth, nutrient and energy status cues to control cell growth and metabolism. While mTORC1 activation at the lysosome is well characterized, it is not clear how this complex is regulated at other subcellular locations. Here, we combi...

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發表在:Nat Commun
Main Authors: Zhou, Xin, Zhong, Yanghao, Molinar-Inglis, Olivia, Kunkel, Maya T., Chen, Mingyuan, Sun, Tengqian, Zhang, Jiao, Shyy, John Y.-J., Trejo, JoAnn, Newton, Alexandra C., Zhang, Jin
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705703/
https://ncbi.nlm.nih.gov/pubmed/33257668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19937-w
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