Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt

mTORC2 lies at the intersection of signaling pathways that control metabolism and ion transport through phosphorylation of the AGC-family kinases, the Akt and SGK1 proteins. How mTORC2 targets these functionally distinct downstream effectors in a context-specific manner is not known. Here, we show t...

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Bibliographic Details
Published in:J Cell Sci
Main Authors: Gleason, Catherine E., Oses-Prieto, Juan A., Li, Kathy H., Saha, Bidisha, Situ, Gavin, Burlingame, Alma L., Pearce, David
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467483/
https://ncbi.nlm.nih.gov/pubmed/30837283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.224931
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