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Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness
Transcriptional memory allows certain genes to respond to previously experienced signals more robustly. However, whether and how the key proinflammatory cytokine TNF-α mediates transcriptional memory are poorly understood. Using HEK293F cells as a model system, we report that sustained TNF-α stimula...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7704108/ https://ncbi.nlm.nih.gov/pubmed/33155547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61965 |
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