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Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness

Transcriptional memory allows certain genes to respond to previously experienced signals more robustly. However, whether and how the key proinflammatory cytokine TNF-α mediates transcriptional memory are poorly understood. Using HEK293F cells as a model system, we report that sustained TNF-α stimula...

詳細記述

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書誌詳細
出版年:eLife
主要な著者: Zhao, Zuodong, Zhang, Zhuqiang, Li, Jingjing, Dong, Qiang, Xiong, Jun, Li, Yingfeng, Lan, Mengying, Li, Gang, Zhu, Bing
フォーマット: Artigo
言語:Inglês
出版事項: eLife Sciences Publications, Ltd 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704108/
https://ncbi.nlm.nih.gov/pubmed/33155547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61965
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