The proinflammatory cytokine TNFα induces DNA demethylation–dependent and –independent activation of interleukin-32 expression

IL-32 is a cytokine involved in proinflammatory immune responses to bacterial and viral infections. However, the role of epigenetic events in the regulation of IL-32 gene expression is understudied. Here we show that IL-32 is repressed by DNA methylation in HEK293 cells. Using ChIP sequencing, locus...

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Vydáno v:J Biol Chem
Hlavní autoři: Zhao, Zuodong, Lan, Mengying, Li, Jingjing, Dong, Qiang, Li, Xiang, Liu, Baodong, Li, Gang, Wang, Hailin, Zhang, Zhuqiang, Zhu, Bing
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497958/
https://ncbi.nlm.nih.gov/pubmed/30824537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006255
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