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The proinflammatory cytokine TNFα induces DNA demethylation–dependent and –independent activation of interleukin-32 expression
IL-32 is a cytokine involved in proinflammatory immune responses to bacterial and viral infections. However, the role of epigenetic events in the regulation of IL-32 gene expression is understudied. Here we show that IL-32 is repressed by DNA methylation in HEK293 cells. Using ChIP sequencing, locus...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6497958/ https://ncbi.nlm.nih.gov/pubmed/30824537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006255 |
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