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Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages

Inflammasomes have been implicated in the detection and clearance of a variety of bacterial pathogens, but little is known about whether this innate sensing mechanism has any regulatory effect on the expression of stimulatory ligands by the pathogen. During infection with Salmonella and many other p...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Akhade, Ajay Suresh, Atif, Shaikh M., Lakshmi, Bhavana S., Dikshit, Neha, Hughes, Kelly T., Qadri, Ayub, Subramanian, Naeha
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703570/
https://ncbi.nlm.nih.gov/pubmed/33177235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002747117
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