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Development of CDK2 and CDK5 Dual Degrader TMX-2172
Cyclin-dependent kinase 2 (CDK2) is a potential therapeutic target for the treatment of cancer. Development of CDK2 inhibitors has been extremely challenging as its ATP-binding site shares high similarity with CDK1, a related kinase whose inhibition causes toxic effects. Here, we report the developm...
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| 出版年: | Angew Chem Int Ed Engl |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7703486/ https://ncbi.nlm.nih.gov/pubmed/32415712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202004087 |
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