Development of CDK2 and CDK5 Dual Degrader TMX-2172

Cyclin-dependent kinase 2 (CDK2) is a potential therapeutic target for the treatment of cancer. Development of CDK2 inhibitors has been extremely challenging as its ATP-binding site shares high similarity with CDK1, a related kinase whose inhibition causes toxic effects. Here, we report the developm...

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Gepubliceerd in:Angew Chem Int Ed Engl
Hoofdauteurs: Teng, Mingxing, Jiang, Jie, He, Zhixiang, Kwiatkowski, Nicholas P., Donovan, Katherine A., Mills, Caitlin E., Victor, Chiara, Hatcher, John M., Fischer, Eric S., Sorger, Peter K., Zhang, Tinghu, Gray, Nathanael S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703486/
https://ncbi.nlm.nih.gov/pubmed/32415712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202004087
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