Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL

Karyotype is an important prognostic factor in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL), but the underlying pharmacogenomics remain unknown. Asparaginase is an integral component in current chemotherapy for childhood BCP-ALL. Asparaginase therapy depletes serum asparagine. N...

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Publicado en:Blood
Autores principales: Watanabe, Atsushi, Miyake, Kunio, Nordlund, Jessica, Syvänen, Ann-Christine, van der Weyden, Louise, Honda, Hiroaki, Yamasaki, Norimasa, Nagamachi, Akiko, Inaba, Toshiya, Ikawa, Tomokatsu, Urayama, Kevin Y., Kiyokawa, Nobutaka, Ohara, Akira, Kimura, Shunsuke, Kubota, Yasuo, Takita, Junko, Goto, Hiroaki, Sakaguchi, Kimiyoshi, Minegishi, Masayoshi, Iwamoto, Shotaro, Shinohara, Tamao, Kagami, Keiko, Abe, Masako, Akahane, Koshi, Goi, Kumiko, Sugita, Kanji, Inukai, Takeshi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2020
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702480/
https://ncbi.nlm.nih.gov/pubmed/32573712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004090
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