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The cannabinoid CB(2) receptor agonist LY2828360 synergizes with morphine to suppress neuropathic nociception and attenuates morphine reward and physical dependence

The opioid crisis has underscored the urgent need to identify safe and effective therapeutic strategies to overcome opioid-induced liabilities. We recently reported that LY2828360, a slowly signaling G protein-biased cannabinoid CB(2) receptor agonist, suppresses neuropathic nociception and attenuat...

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Détails bibliographiques
Publié dans:Eur J Pharmacol
Auteurs principaux: Iyer, Vishakh, Slivicki, Richard A., Thomaz, Ana C., Crystal, Jonathon D., Mackie, Ken, Hohmann, Andrea G.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7694697/
https://ncbi.nlm.nih.gov/pubmed/32896549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2020.173544
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