Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy

The synucleinopathy underlying multiple system atrophy (MSA) is characterized by the presence of abundant amyloid inclusions containing fibrillar α-synuclein (α-syn) aggregates in the brains of the patients and is associated with an extensive neurodegeneration. In contrast to Parkinson’s disease (PD...

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Détails bibliographiques
Publié dans:Cells
Auteurs principaux: Laferrière, Florent, He, Xin, Zinghirino, Federica, Doudnikoff, Evelyne, Faggiani, Emilie, Meissner, Wassilios G., Bezard, Erwan, De Giorgi, Francesca, Ichas, François
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693764/
https://ncbi.nlm.nih.gov/pubmed/33138150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9112371
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