Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons

The conformational strain diversity characterizing α-synuclein (α-syn) amyloid fibrils is thought to determine the different clinical presentations of neurodegenerative diseases underpinned by a synucleinopathy. Experimentally, various α-syn fibril polymorphs have been obtained from distinct fibrill...

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Publicado en:Sci Adv
Main Authors: De Giorgi, Francesca, Laferrière, Florent, Zinghirino, Federica, Faggiani, Emilie, Lends, Alons, Bertoni, Mathilde, Yu, Xuan, Grélard, Axelle, Morvan, Estelle, Habenstein, Birgit, Dutheil, Nathalie, Doudnikoff, Evelyne, Daniel, Jonathan, Claverol, Stéphane, Qin, Chuan, Loquet, Antoine, Bezard, Erwan, Ichas, François
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852382/
https://ncbi.nlm.nih.gov/pubmed/33008896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc4364
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