Rational Design of a DNA‐Scaffolded High‐Affinity Binder for Langerin

Binders of langerin could target vaccines to Langerhans cells for improved therapeutic effect. Since langerin has low affinity for monovalent glycan ligands, highly multivalent presentation has previously been key for targeting. Aiming to reduce the amount of ligand required, we rationally designed...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Bachem, Gunnar, Wamhoff, Eike‐Christian, Silberreis, Kim, Kim, Dongyoon, Baukmann, Hannes, Fuchsberger, Felix, Dernedde, Jens, Rademacher, Christoph, Seitz, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693190/
https://ncbi.nlm.nih.gov/pubmed/32749019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202006880
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