Rational Design of a DNA‐Scaffolded High‐Affinity Binder for Langerin

Binders of langerin could target vaccines to Langerhans cells for improved therapeutic effect. Since langerin has low affinity for monovalent glycan ligands, highly multivalent presentation has previously been key for targeting. Aiming to reduce the amount of ligand required, we rationally designed...

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Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: Bachem, Gunnar, Wamhoff, Eike‐Christian, Silberreis, Kim, Kim, Dongyoon, Baukmann, Hannes, Fuchsberger, Felix, Dernedde, Jens, Rademacher, Christoph, Seitz, Oliver
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693190/
https://ncbi.nlm.nih.gov/pubmed/32749019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202006880
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