Rational Design of a DNA‐Scaffolded High‐Affinity Binder for Langerin

Binders of langerin could target vaccines to Langerhans cells for improved therapeutic effect. Since langerin has low affinity for monovalent glycan ligands, highly multivalent presentation has previously been key for targeting. Aiming to reduce the amount of ligand required, we rationally designed...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Angew Chem Int Ed Engl
Main Authors: Bachem, Gunnar, Wamhoff, Eike‐Christian, Silberreis, Kim, Kim, Dongyoon, Baukmann, Hannes, Fuchsberger, Felix, Dernedde, Jens, Rademacher, Christoph, Seitz, Oliver
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693190/
https://ncbi.nlm.nih.gov/pubmed/32749019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202006880
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares