Switching the Switch: Ligand Induced Disulfide Formation in HDAC8

Human histone deacetylase 8 is a well‐recognized target for T‐cell lymphoma and particularly childhood neuroblastoma. PD‐404,182 was shown to be a selective covalent inhibitor of HDAC8 that forms mixed disulfides with several cysteine residues and is also able to transform thiol groups to thiocyanat...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Chemistry
Autores principales: Jänsch, Niklas, Sugiarto, Wisely Oki, Muth, Marius, Kopranovic, Aleksandra, Desczyk, Charlotte, Ballweg, Matthias, Kirschhöfer, Frank, Brenner‐Weiss, Gerald, Meyer‐Almes, Franz‐Josef
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7692948/
https://ncbi.nlm.nih.gov/pubmed/32428298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202001712
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares