Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation

Epigenetics plays a fundamental role in cancer progression, and developing agents that regulate epigenetics is crucial for cancer management. Among Class I and Class II HDACs, HDAC8 is one of the essential epigenetic players in cancer progression. Therefore, we designed, synthesized, purified, and s...

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Published in:Bioorg Chem
Main Authors: Upadhyay, Neha, Tilekar, Kalpana, Jänsch, Niklas, Schweipert, Markus, Hess, Jessica D., Macias, Luca Henze, Mrowka, Piotr, Aguilera, Renato J., Choe, Jun-yong, Meyer-Almes, Franz-Josef, Ramaa, C S
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7302971/
https://ncbi.nlm.nih.gov/pubmed/32446120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2020.103934
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