Switching the Switch: Ligand Induced Disulfide Formation in HDAC8

Human histone deacetylase 8 is a well‐recognized target for T‐cell lymphoma and particularly childhood neuroblastoma. PD‐404,182 was shown to be a selective covalent inhibitor of HDAC8 that forms mixed disulfides with several cysteine residues and is also able to transform thiol groups to thiocyanat...

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Bibliografski detalji
Izdano u:Chemistry
Glavni autori: Jänsch, Niklas, Sugiarto, Wisely Oki, Muth, Marius, Kopranovic, Aleksandra, Desczyk, Charlotte, Ballweg, Matthias, Kirschhöfer, Frank, Brenner‐Weiss, Gerald, Meyer‐Almes, Franz‐Josef
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Full Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7692948/
https://ncbi.nlm.nih.gov/pubmed/32428298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202001712
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