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Switching the Switch: Ligand Induced Disulfide Formation in HDAC8
Human histone deacetylase 8 is a well‐recognized target for T‐cell lymphoma and particularly childhood neuroblastoma. PD‐404,182 was shown to be a selective covalent inhibitor of HDAC8 that forms mixed disulfides with several cysteine residues and is also able to transform thiol groups to thiocyanat...
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| 出版年: | Chemistry |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7692948/ https://ncbi.nlm.nih.gov/pubmed/32428298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202001712 |
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