Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues

Mutations in LRRK2 cause familial Parkinson’s disease and common variants increase disease risk. LRRK2 kinase activity and cellular localization are tightly regulated by phosphorylation of key residues, primarily Ser1292 and Ser935, which impacts downstream phosphorylation of its substrates, among w...

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Publicado en:Cells
Main Authors: Iannotta, Lucia, Biosa, Alice, Kluss, Jillian H., Tombesi, Giulia, Kaganovich, Alice, Cogo, Susanna, Plotegher, Nicoletta, Civiero, Laura, Lobbestael, Evy, Baekelandt, Veerle, Cookson, Mark R., Greggio, Elisa
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7690595/
https://ncbi.nlm.nih.gov/pubmed/33105882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9112344
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