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Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation
Leucine-rich repeat kinase 2 (LRRK2) kinase activity is increased in several pathogenic mutations, including the most common mutation, G2019S, and is known to play a role in Parkinson’s disease (PD) pathobiology. This has stimulated the development of potent, selective LRRK2 kinase inhibitors as one...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5034242/ https://ncbi.nlm.nih.gov/pubmed/27658356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33897 |
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