Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

Genetic studies show that LRRK2, and not its closest paralogue LRRK1, is linked to Parkinson’s disease. To gain insight into the molecular and cellular basis of this discrepancy, we searched for LRRK1- and LRRK2-specific cellular processes by identifying their distinct interacting proteins. A protei...

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Publicat a:J Neurochem
Autors principals: Reyniers, Lauran, Del Giudice, Maria Grazia, Civiero, Laura, Belluzzi, Elisa, Lobbestael, Evy, Beilina, Alexandra, Arrigoni, Giorgio, Derua, Rita, Waelkens, Etienne, Li, Yan, Crosio, Claudia, Iaccarino, Ciro, Cookson, Mark R., Baekelandt, Veerle, Greggio, Elisa, Taymans, Jean-Marc
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272680/
https://ncbi.nlm.nih.gov/pubmed/24947832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12798
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