Whole blood viscosity and red blood cell adhesion: Potential biomarkers for targeted and curative therapies in sickle cell disease

Sickle cell disease (SCD) is a recessive genetic blood disorder exhibiting abnormal blood rheology. Polymerization of sickle hemoglobin, due to a point mutation in the β‐globin gene of hemoglobin, results in aberrantly adhesive and stiff red blood cells (RBCs). Hemolysis, abnormal RBC adhesion, and...

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Vydáno v:Am J Hematol
Hlavní autoři: Kucukal, Erdem, Man, Yuncheng, Hill, Ailis, Liu, Shichen, Bode, Allison, An, Ran, Kadambi, Jaikrishnan, Little, Jane A., Gurkan, Umut A.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689825/
https://ncbi.nlm.nih.gov/pubmed/32656816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.25933
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