Basal Histamine H(4) Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif

Histamine H(4) receptor (H(4)R) orthologues are G‐protein‐coupled receptors (GPCRs) that exhibit species‐dependent basal activity. In contrast to the basally inactive mouse H(4)R (mH(4)R), human H(4)R (hH(4)R) shows a high degree of basal activity. We have performed long‐timescale molecular dynamics...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Wifling, David, Pfleger, Christopher, Kaindl, Jonas, Ibrahim, Passainte, Kling, Ralf C., Buschauer, Armin, Gohlke, Holger, Clark, Timothy
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7687114/
https://ncbi.nlm.nih.gov/pubmed/31498478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201902801
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