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Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H(2) Receptor Agonists†
[Image: see text] On the basis of the long-known prototypic pharmacophore 3-(1H-imidazol-4-yl)propylguanidine (SK&F 91486, 2), monomeric, homodimeric, and heterodimeric bisalkylguanidine-type histamine H(2) receptor (H(2)R) agonists with various alkyl spacers were synthesized. Aiming at increase...
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| Publicado no: | ACS Omega |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical
Society
2018
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6130797/ https://ncbi.nlm.nih.gov/pubmed/30221224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00128 |
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