Basal Histamine H(4) Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif

Histamine H(4) receptor (H(4)R) orthologues are G‐protein‐coupled receptors (GPCRs) that exhibit species‐dependent basal activity. In contrast to the basally inactive mouse H(4)R (mH(4)R), human H(4)R (hH(4)R) shows a high degree of basal activity. We have performed long‐timescale molecular dynamics...

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Bibliografiska uppgifter
I publikationen:Chemistry
Huvudupphovsmän: Wifling, David, Pfleger, Christopher, Kaindl, Jonas, Ibrahim, Passainte, Kling, Ralf C., Buschauer, Armin, Gohlke, Holger, Clark, Timothy
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
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Full Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7687114/
https://ncbi.nlm.nih.gov/pubmed/31498478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201902801
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