High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli

Understanding the constraints that shape the evolution of antibiotic resistance is critical for predicting and controlling drug resistance. Despite its importance, however, a systematic investigation of evolutionary constraints is lacking. Here, we perform a high-throughput laboratory evolution of E...

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Publicado en:Nat Commun
Main Authors: Maeda, Tomoya, Iwasawa, Junichiro, Kotani, Hazuki, Sakata, Natsue, Kawada, Masako, Horinouchi, Takaaki, Sakai, Aki, Tanabe, Kumi, Furusawa, Chikara
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686311/
https://ncbi.nlm.nih.gov/pubmed/33235191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19713-w
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