High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli

Understanding the constraints that shape the evolution of antibiotic resistance is critical for predicting and controlling drug resistance. Despite its importance, however, a systematic investigation of evolutionary constraints is lacking. Here, we perform a high-throughput laboratory evolution of E...

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Udgivet i:Nat Commun
Main Authors: Maeda, Tomoya, Iwasawa, Junichiro, Kotani, Hazuki, Sakata, Natsue, Kawada, Masako, Horinouchi, Takaaki, Sakai, Aki, Tanabe, Kumi, Furusawa, Chikara
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686311/
https://ncbi.nlm.nih.gov/pubmed/33235191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19713-w
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