Beta-adrenergic receptor antagonism is proinflammatory and exacerbates neuroinflammation in a mouse model of Alzheimer’s Disease

Adrenergic systems regulate both cognitive function and immune function. The primary source of adrenergic signaling in the brain is norepinephrine (NE) neurons of the locus coeruleus (LC), which are vulnerable to age-related degeneration and are one of the earliest sites of pathology and degeneratio...

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Bibliographische Detailangaben
Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Evans, Andrew K., Ardestani, Pooneh, Yi, Bitna, Park, Heui Hye, Lam, Rachel, Shamloo, Mehrdad
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686098/
https://ncbi.nlm.nih.gov/pubmed/32971233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.105089
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