Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APP(Swe) Mouse Models of Tauopathy and Amyloidosis

Emerging evidence suggests that endoplasmic reticulum (ER) stress may be involved in the pathogenesis of Alzheimer’s disease (AD). Recently, pharmacological modulation of the eukaryotic translation initiation factor-2 (eIF2α) pathway was achieved using an integrated stress response inhibitor (ISRIB)...

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Bibliografiset tiedot
Julkaisussa:eNeuro
Päätekijät: Briggs, Denise Isabelle, Defensor, Erwin, Memar Ardestani, Pooneh, Yi, Bitna, Halpain, Michelle, Seabrook, Guy, Shamloo, Mehrdad
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for Neuroscience 2017
Aiheet:
New Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510086/
https://ncbi.nlm.nih.gov/pubmed/28721361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0025-17.2017
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