Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APP(Swe) Mouse Models of Tauopathy and Amyloidosis

Emerging evidence suggests that endoplasmic reticulum (ER) stress may be involved in the pathogenesis of Alzheimer’s disease (AD). Recently, pharmacological modulation of the eukaryotic translation initiation factor-2 (eIF2α) pathway was achieved using an integrated stress response inhibitor (ISRIB)...

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發表在:eNeuro
Main Authors: Briggs, Denise Isabelle, Defensor, Erwin, Memar Ardestani, Pooneh, Yi, Bitna, Halpain, Michelle, Seabrook, Guy, Shamloo, Mehrdad
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2017
主題:
New Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510086/
https://ncbi.nlm.nih.gov/pubmed/28721361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0025-17.2017
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