Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APP(Swe) Mouse Models of Tauopathy and Amyloidosis

Emerging evidence suggests that endoplasmic reticulum (ER) stress may be involved in the pathogenesis of Alzheimer’s disease (AD). Recently, pharmacological modulation of the eukaryotic translation initiation factor-2 (eIF2α) pathway was achieved using an integrated stress response inhibitor (ISRIB)...

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Dettagli Bibliografici
Pubblicato in:eNeuro
Autori principali: Briggs, Denise Isabelle, Defensor, Erwin, Memar Ardestani, Pooneh, Yi, Bitna, Halpain, Michelle, Seabrook, Guy, Shamloo, Mehrdad
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2017
Soggetti:
New Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510086/
https://ncbi.nlm.nih.gov/pubmed/28721361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0025-17.2017
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