Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APP(Swe) Mouse Models of Tauopathy and Amyloidosis

Emerging evidence suggests that endoplasmic reticulum (ER) stress may be involved in the pathogenesis of Alzheimer’s disease (AD). Recently, pharmacological modulation of the eukaryotic translation initiation factor-2 (eIF2α) pathway was achieved using an integrated stress response inhibitor (ISRIB)...

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Detalhes bibliográficos
Publicado no:eNeuro
Main Authors: Briggs, Denise Isabelle, Defensor, Erwin, Memar Ardestani, Pooneh, Yi, Bitna, Halpain, Michelle, Seabrook, Guy, Shamloo, Mehrdad
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
New Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510086/
https://ncbi.nlm.nih.gov/pubmed/28721361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0025-17.2017
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