Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APP(Swe) Mouse Models of Tauopathy and Amyloidosis

Emerging evidence suggests that endoplasmic reticulum (ER) stress may be involved in the pathogenesis of Alzheimer’s disease (AD). Recently, pharmacological modulation of the eukaryotic translation initiation factor-2 (eIF2α) pathway was achieved using an integrated stress response inhibitor (ISRIB)...

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Bibliografiske detaljer
Udgivet i:eNeuro
Main Authors: Briggs, Denise Isabelle, Defensor, Erwin, Memar Ardestani, Pooneh, Yi, Bitna, Halpain, Michelle, Seabrook, Guy, Shamloo, Mehrdad
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2017
Fag:
New Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510086/
https://ncbi.nlm.nih.gov/pubmed/28721361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0025-17.2017
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