Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer’s Disease using a biased and selective beta-1 adrenergic receptor partial agonist

Degeneration of noradrenergic neurons occurs at an early stage of Alzheimer’s Disease (AD). The noradrenergic system regulates arousal and learning and memory, and has been implicated in regulating neuroinflammation. Loss of noradrenergic tone may underlie AD progression at many levels. We have prev...

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Bibliografske podrobnosti
izdano v:Neuropharmacology
Main Authors: Ardestani, Pooneh Memar, Evans, Andrew K., Yi, Bitna, Nguyen, Tiffany, Coutellier, Laurence, Shamloo, Mehrdad
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385159/
https://ncbi.nlm.nih.gov/pubmed/28089846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.01.010
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