Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders

The beta-1 adrenergic receptor (ADRB1) is a promising therapeutic target intrinsically involved in the cognitive deficits and pathological features associated with Alzheimer’s disease (AD). Evidence indicates that ADRB1 plays an important role in regulating neuroinflammatory processes, and activatio...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Yi, Bitna, Jahangir, Alam, Evans, Andrew K., Briggs, Denise, Ravina, Kristine, Ernest, Jacqueline, Farimani, Amir B., Sun, Wenchao, Rajadas, Jayakumar, Green, Michael, Feinberg, Evan N., Pande, Vijay S., Shamloo, Mehrdad
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529018/
https://ncbi.nlm.nih.gov/pubmed/28746336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180319
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