Beta-adrenergic receptor antagonism is proinflammatory and exacerbates neuroinflammation in a mouse model of Alzheimer’s Disease

Adrenergic systems regulate both cognitive function and immune function. The primary source of adrenergic signaling in the brain is norepinephrine (NE) neurons of the locus coeruleus (LC), which are vulnerable to age-related degeneration and are one of the earliest sites of pathology and degeneratio...

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Bibliografiske detaljer
Udgivet i:Neurobiol Dis
Main Authors: Evans, Andrew K., Ardestani, Pooneh, Yi, Bitna, Park, Heui Hye, Lam, Rachel, Shamloo, Mehrdad
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686098/
https://ncbi.nlm.nih.gov/pubmed/32971233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.105089
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